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Environmentally Induced Oxidative Stress Toxicology

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Toxicology".

Deadline for manuscript submissions: 30 June 2024 | Viewed by 480

Special Issue Editor


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Guest Editor
1. Environmental Health and Drug Department, Yokohama University of Pharmacy, 601 Matano-cho, Totsuka, Yokohama 2450066, Japan
2. National Institute for Environmental Studies, Center for Health and Environmental Risk Research, 16-2 Onogawa, Tsukuba 3058506, Ibraki, Japan
Interests: health and disease in humans and animals; risk assessment of cancer; reproduction; child development; objective methods for epidemiology; in vivo, in vitro and in silico; mechanism sciences; exposure sciences for food and drinking; use and application of stem cells in toxicology
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Special Issue Information

Dear Colleagues,

Oxidative stress is arguably the most common mechanism in the toxicology of environmental agents, unifying the action of broad classes of physicochemically disparate environmental pollutants, including oxidant gases, organic compounds, particulate surfaces, and metal ions. As advances in redox biology identify previously unrecognized targets for disruption by exposure to xenobiotics, redox toxicology has emerged as a new field of investigation. Environmental contaminants can induce oxidative stress on cells through mechanisms that are direct, indirect, or involve the disruption of metabolic or bioenergetic processes that are regulated by thiol redox switches.

This Special Issue aims to collect original research and review articles that address all aspects of environmental pollutants and their mechanisms of action linked with oxidative stress, inflammation, and cell death in human diseases or using animal models.

Prof. Dr. Hideko Sone
Guest Editor

Manuscript Submission Information

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Keywords

  • oxidative stress
  • environmental toxicology
  • environmental contaminants
  • inflammation
  • cell death
  • animal models

Published Papers (1 paper)

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Research

13 pages, 3901 KiB  
Article
Accumulation of Alpha-Synuclein and Increase in the Inflammatory Response in the substantia nigra, Jejunum, and Colon in a Model of O3 Pollution in Rats
by Marlen Valdés-Fuentes, Erika Rodríguez-Martínez and Selva Rivas-Arancibia
Int. J. Mol. Sci. 2024, 25(10), 5526; https://doi.org/10.3390/ijms25105526 - 18 May 2024
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Abstract
This work aimed to study the effect of repeated exposure to low doses of ozone on alpha-synuclein and the inflammatory response in the substantia nigra, jejunum, and colon. Seventy-two male Wistar rats were divided into six groups. Each group received one of [...] Read more.
This work aimed to study the effect of repeated exposure to low doses of ozone on alpha-synuclein and the inflammatory response in the substantia nigra, jejunum, and colon. Seventy-two male Wistar rats were divided into six groups. Each group received one of the following treatments: The control group was exposed to air. The ozone groups were exposed for 7, 15, 30, 60, and 90 days for 0.25 ppm for four hours daily. Afterward, they were anesthetized, and their tissues were extracted and processed using Western blotting, immunohistochemistry, and qPCR. The results indicated a significant increase in alpha-synuclein in the substantia nigra and jejunum from 7 to 60 days of exposure and an increase in NFκB from 7 to 90 days in the substantia nigra, while in the jejunum, a significant increase was observed at 7 and 15 days and a decrease at 60 and 90 days for the colon. Interleukin IL-17 showed an increase at 90 days in the substantia nigra in the jejunum and increases at 30 days and in the colon at 15 and 90 days. Exposure to ozone increases the presence of alpha-synuclein and induces the loss of regulation of the inflammatory response, which contributes significantly to degenerative processes. Full article
(This article belongs to the Special Issue Environmentally Induced Oxidative Stress Toxicology)
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